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Holby City
Season 21
Episode 42

Hope is a Powerful Drug

October 15, 2019

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Holby City - S21 - E42

Essie is torn when Frankie returns wanting to take Isla home, Ric is caught between Serena and top neurosurgeon Max McGerry as they clash over his treatment options, and Jac returns from holiday and wastes no time in winding up a stressed Kian.

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Holby City: Season 21 - 53 Episode s

21x1 - Everything Old Is New Again
January 2, 2019
Jac, Ric and Sacha face off against old rivals while pitching for a million-pound prize fund. But as the competition threatens to divide the group, should they be more worried about their friends than their enemies? Serena's new year is once again marked by tragedy when a loved one is brought in for emergency surgery. Dare Serena put her personal feelings aside and perform the operation to prevent history repeating itself?
21x2 - China Crisis
January 8, 2019
A surprise blast from the distant past returns to run a Young Adult Unit alongside top consultant Ange Godard. He successfully puts everyone on tenterhooks with his notorious barbs and quips, until things take a surprising turn, much to everyone's surprise. Nicky competes with Cameron for the junior doctor lead position only to realise that high accolades aren't everything when it to come to surgery. Serena steps in to protect her ward when an old face from the past turns up and offends them. Serena fails to see the funny side and takes control.
21x3 - The Burden of Proof
January 15, 2019
Ange finally allows Dominic the chance to work on her new unit, after much persistence, but she isn't sure whether he has the chops to be a great doctor. When Dominic is economical with the truth, Ange has to confront him and then feels that he's not trustworthy. Nicky and Cameron find common ground when they have to work alongside an unforgiving Jac. Struggling to prove that he's worthy, Cameron goes all out to impress her. When things go wrong, will Cameron be forced to confront his own mistakes? Ric's former wife Lola returns to Holby to work alongside her former flame on AAU. Serena and Zav are highly amused by the tension between them, but Ric soon realises that he actually has residual feelings for his ex. But are they reciprocated?
21x4 - A Daring Adventure or Nothing at All
January 22, 2019
Frieda is happy her life is on an even keel, but her contentment is shattered when her ex-boyfriend Roman unexpectedly reappears. Can a wary Frieda open her heart and dare to imagine a future she had thought was gone for good? With their relationship going well, Xavier is keen to step up and ease the burdens weighing on a stressed Donna. But all does not entirely go to plan when Zav embarks on some impromptu parenting of Mia. Ange feels the pressure as she works to sell her vision for her Young Adult Unit while treating a difficult and vulnerable patient. But striving to be all things to all people, Ange fails to get to grips with the behaviour of a returning colleague who might really need help.
21x5 - Mad as Hell
January 29, 2019
When Holby is overwhelmed by a winter crisis, Ric goes above and beyond to treat his patients. But as the pressure reaches fever pitch, can he continue to accept Holby surviving on nothing more than good will and the occasional miracle? To Jac and Fletch's concern, a grief-stricken Frieda immerses herself completely in work, but when she's challenged by a patient's confrontational father, and with her emotions running high, Frieda embarks on a fight she has to win. When Ange has her work cut out on YAU thanks to an obstinate teenager, it's down to Essie to persuade an unwilling Ange to enlist help from a source who's a bit too close to home.
21x6 - Force Majeure
February 5, 2019
When a family secret is exposed, the dispute causes a young patient to delay vital surgery, but fearing the consequences of such a decision, a concerned Ange must find a way to make her reconsider. Keen to highlight the constant pressures Holby faces on a daily basis, Ric enlists the help of an influential acquaintance. But when an innocent patient is caught up in his personal crusade will Ric do the right thing? When the opportunity to attend an overseas conference arises, Nicky and Cameron must battle it out, but with Nicky running on empty does she have the strength to come out on top?
21x7 - Good Side
February 12, 2019
While Holly's condition weighs heavily on an emotionally invested Ange, Holly's distraught parents must put their differences aside to make a heartbreaking decision, but are they prepared for what lies ahead? When new locum Chloe covers on Darwin, a smitten Cameron sets out to impress, but with a tricky patient keeping him on his toes will Cameron step up to the plate? There's no love lost between Xavier and Carole, so when a disgruntled Xavier is tasked with treating spiritual Carole, it's clear she's not the only one in pain.
21x8 - Never Say Never
February 19, 2019
Zosia arrives at Holby keen to get back working on Darwin. With her knack for irritating Jac in full swing, will Jac be able to track down Frieda before Zosia gets too comfortable? Ange struggles with Holly's parents who are intent on fighting for their daughter. When an offer of hope for radical treatment comes from America, Ange does her best to make them see what is really best for their daughter. Donna and Xavier struggle to keep their domestic arguments at home - will being forced to work closely together for the day sort out their differences or drive them further apart?
21x9 - Guts
February 26, 2019
Zosia's big news gets a mixed response, and Jac remains suspicious about her real reasons for returning to Holby. Zosia's situation is further complicated when a handsome American turns up wanting to tempt her back across the Atlantic. Sasha is rattled and embarrassed when an old flame appears on the ward with their ill partner. Following diagnosis, Sasha gets to try out his new transplant procedure and by the end of the day has two reasons to celebrate. Following an incident with protestors, Jason refuses to leave Hanssen's office until his demands are met. Despite Serena’s pleading, he stands firm and eventually a difficult decision is made about a long-term patient, much to Ange’s annoyance.
21x10 - Powerless
March 5, 2019
A computer virus shuts down Holby’s power, putting Jac and Connie at loggerheads as they fight against all odds and in makeshift conditions to save the lives of close friends and colleagues. During a hospital-wide evacuation, Ric mounts a daring rescue for a trapped and weakening Essie – even as he struggles with a shocking revelation about Darla. In the midst of chaos, can Ange and Serena agree on how best to care for Holly, who continues on life-support?
21x11 - A Simple Lie, Part 1
March 19, 2019
A desperate Ange pleads with Holly’s family to see reason, but when the ruling comes back, the anger finally boils over with devastating consequences for Fletch. Ric's son Kofi arrives at Holby wanting to find out what’s going on with Darla. Struggling to keep his granddaughter's pregnancy a secret, Ric battles to keep his family together and do what’s right for everyone. An excited Zosia looks forward to working with Frieda, only she doesn’t get the reception she was expecting. As the pair team up to tackle a case, Zosia does her best to win over Frieda, with hilarious results.
21x12 - A Simple Lie, Part Two
March 20, 2019
As the protesters grow angrier Holby tightens security, Fletch realises there may be darker forces at play with Theo’s disappearance. Chloe struggles to decide if staying at Holby is the right thing to do. Dom tries to persuade her, but is thrown off by a surprise visitor. A romantic evening doesn’t go as planned for Xavier and Donna when his mother arrives, putting Donna in a difficult position.
21x13 - Running
March 26, 2019
Ange follows a hunch and ends up uncovering a shocking and long buried secret – one with the potential to tear her life completely apart. A downbeat Frieda faces tough choices when an old friend of Roman’s appears in Holby in desperate need of help. Can she manage to work within the system and play by the rules? Cameron and Xavier are forced together on Darwin, where Xavier appears to take delight in Cameron’s dating woes.
21x14 - Ask No Questions
April 2, 2019
Chloe is surprised and immediately wrongfooted when ex-boyfriend Evan unexpectedly turns up on Darwin Ward. Is it possible he’s simply there to care for his sister Phoebe? As Ange reels from her recent earth-shattering discovery and tries to plan her next move, Carole unexpectedly confronts Dominic with painful and long-buried secrets from his past. In the midst of a chaotic shift, Donna is surprised by Mia’s unexpected appearance – forcing Donna to navigate some sensitive parenting territory.
21x15 - The Family Way
April 9, 2019
A bewildered Dom struggles to come to terms with a shocking family secret and he immerses himself in work. However being around Ange proves difficult, causing Dom to make a drastic decision about his career. Will Ange convince Dom to change his mind? Donna will do anything to protect her daughter, but when she oversteps the line in a well-meaning attempt to shield Mia, Donna’s parenting is called into question. Though Serena offers some sound advice, can Donna accept Mia is growing up? An enthusiastic Zosia is keen to take on more challenging cases but Jac, still privately resentful towards Zosia, sidelines her. Feeling disgruntled, Zosia undermines Jac’s authority, but it only adds strain to their already fraught relationship.
21x16 - North and South
April 16, 2019
A startling incident forces Zosia to reconsider her future at Holby, Cameron has to treat a close relative of Xavier's, and Dom tries to keep Carole at arm's length.
21x17 - Pleased to Meet You
April 23, 2019
Jac’s top-dog status is challenged when a talented new surgeon starts at Holby and instantly causes a stir. Dom is irritated when Carole starts work on reception, and Ange tries to limit family fallout. Donna is flattered to be offered a new career opportunity, but does she really want the extra responsibility?
21x18 - Vinegar and Honey
April 30, 2019
Kian’s big personality and alternative methods are beginning to grate on Jac, but is it just a case of professional jealousy? Fletch reminds her that she’s only as good as her team and should allow him to thrive. Dom tells Ange he wants to be a proper part of her and Chloe’s lives. In response Ange finally opens up to Dom, revealing a big family secret. When Sue makes a big mistake on her first day at the new job, Donna covers it up. However being the favourite of the new boss poses new challenges.
21x19 - Ex Marks the Spot
May 7, 2019
Ange plans to tell Chloe her biggest secret, but a surprise locum throws her day into disarray. Ric’s granddaughter, Darla, arrives at Holby, forcing Ric to deal with her pregnancy head on. Kian rallies Nicky and Cameron to help him find out who Jac’s mystery patient is.
21x20 - The Wrong Horse
May 14, 2019
As Chloe tries to come to terms with the news that Dominic is her half-brother, she’s forced to operate with him and Ange. But as tension boils over and Evan helps her uncover a home truth, will Chloe be able to cope? Lofty returns to Holby after the holiday of a lifetime. With something clearly on his mind, he wants to speak to Dominic but misses his moment when he learns that Ange is Dominic’s birth mother. But what is Lofty hiding, and who is just around the corner? When an infestation of rodents takes refuge at Sacha’s home, he decides it’s time to move out of Jac’s house and leave her in peace. Jac worries whether he’s really ready, but what will Sacha do to convince her?
21x21 - Unredeemed
May 21, 2019
Dominic faces his difficult past when he goes head to head with his abusive ex, Isaac. Ange and Carole band together in order to cope with the fact that Isaac has returned, affecting Dominic’s life. Jac’s conscience is thrown into conflict when she meets a previous patient who has something she wants. How far will she go for personal gain?
21x22 - Bloodline
May 28, 2019
Will Lofty and Dom’s marriage survive under the pressure of Isaac’s presence at Holby, and is Sacha’s relationship with Patricia over before it’s even begun?
21x23 - In the Right Place
June 4, 2019
As Dom and Isaac grow closer, is Dom at risk of falling under his spell? Hanssen finds himself in unfamiliar territory when an estranged relative arrives at Holby, and Chloe gets an unpleasant surprise when she returns to work.
21x24 - Over My Dead Body
June 11, 2019
The manipulative Isaac continues to drive a wedge between Dom and Lofty, but when Isaac puts Lofty in harm’s way and the net is closing in, is Isaac’s fate sealed? Good intentions backfire for Cameron when an intervention doesn’t go his way, but when faced with an opportunity to protect Chloe, Cameron makes a selfless gesture. Hanssen must navigate the world of parenting to figure out what’s troubling his unusually quiet grandson Oskar.
21x25 - Pigeon
June 20, 2019
When Xavier’s mum arrives on AAU talking in riddles, Donna does her best to shelter him from her behaviour - but will he appreciate the intervention? Sacha makes a romantic gesture but finds something unexpected in Patricia’s cleaning cupboard. Nicky turns her nose up at working with Jac, who ensures she’ll live to regret it.
21x26 - Kiss Kiss
June 25, 2019
Xavier tries to build bridges with Donna, but she’s having none of it. Cameron can’t quite shift his feelings of unease around Evan, and when he overhears a phone call his suspicions are confirmed. And Fletch is anxious about his first official date with Ange, especially when work threatens to get in the way.
21x27 - Flying Solo
July 9, 2019
Cameron tries to prove himself to Kian, but they clash over Kian's teaching methods. A frustrated Xavier gets relationship advice from the most unlikely source, and Carole opens up to Hanssen about her woes with Dominic and impending divorce.
21x28 - Reckless
July 10, 2019
Chloe’s day is thrown into chaos when Evan is attacked. With his life on the line, Evan asks Chloe a surprising question. Dominic is put under pressure when a surprise visitor arrives at Holby looking for Lofty. Wanting to keep his marriage intact, Dominic is forced to make a difficult decision. And after a night of partying together, Serena and Fleur Fanshawe are thrown together to help a patient on AAU.
21x29 - Honeymoon
July 16, 2019
As her loved ones continue to worry about her, Chloe learns more about Evan. Cameron wants to get out from under Bernie’s shadow, but he receives some devastating news. Hanssen learns that his grandson is not the only one who believes in the tooth fairy.
21x30 - Don't Leave Me
July 23, 2019
On the anniversary of a personal tragedy, Kian decides he must save a life today. Hanssen worries that with his family history he shouldn’t look after Oskar and wonders whether nature or nurture will have a greater effect on his grandson. Cameron struggles to accept some recent news and refuses help from Alex. When Serena tries to help him, she receives surprising news.
21x31 - Things My Mother Told Me
July 30, 2019
As the Holby team give a warm send off to a much beloved colleague, a surprising revelation sends Cameron into a spin. However, Cameron crosses the line when his drunken behaviour spills onto the ward.
21x32 - When Worlds Collide
August 6, 2019
Jac’s work-life balance is called into question when her ex’s new fiancee arrives at Holby with Emma in tow, and she’s forced to make a career changing decision. Will life on Darwin ever be the same? As Serena's tough façade slowly unravels, is grief finally catching up with her? And Dominic is on a mission to find out what Hanssen and Carole are secretly up to.
21x33 - Work-Life Balance
August 13, 2019
Is Chloe brave enough to tell Evan she wants a divorce? And what will he do if she does? Faced with choosing between work and his personal life, will Hanssen learn from past mistakes? And will having their therapist as a patient bring Dom and Lofty closer or push them further apart?
21x34 - Where Does It Hurt?
August 20, 2019
A distressed stranger turns up looking for Raf di Lucca. Will her secret change Essie’s life forever? Xav questions Ric’s competence, but is Ric’s outrage hiding a graver concern? Nicky learns to trust her instincts – and that includes suspicions about sinister Evan too.
21x35 - Babysitters and Bystanders
August 27, 2019
Chloe's day is thrown into chaos when Evan's sister, Phoebe, returns to Holby. Essie is left torn when she is forced to make a difficult decision, and a high profile patient is admitted to AAU, but are things exactly as they seem?
21x36 - The Perfect Storm
September 3, 2019
Jac is rocked when Faye Morton returns to Holby bringing Joseph with her. Sacha struggles to do the right thing for a family grieving their mother.
21x37 - Gods and Monsters
September 10, 2019
A friendly face from the past gives Ric someone to confide in. Fletch goes on a mission that could cost him his relationship with Ange.
21x38 - Circle of Life
September 17, 2019
Fearing something may be wrong with him, Ric is absent when his granddaughter, Darla, goes into early labour. When Isla requires emergency surgery, Essie’s lie that she’s her adopted mother is in danger of being exposed. And as Chloe tries to move on from Evan, she has a feeling that he’s watching her.
21x39 - Retreat
September 24, 2019
Evan refuses to give up on Chloe and proves what a real threat he can be. Cameron abandons his quest to help Ric when he receives heart-breaking news.
21x40 - Divine Justice
October 1, 2019
Will it be Chloe or Evan’s version of events that will be believed? How can a grieving Cameron make amends for failing Chloe when she needed him most? And what will an MRI scan reveal about Ric’s future?
21x41 - This Be the Verse
October 8, 2019
Both Ric and Darla are faced with life-changing decisions, an aggressive stranger at the hospital threatens to blow Essie’s baby secret wide open, and will Kian be able to mend the heart of an old flame?
21x42 - Hope is a Powerful Drug
October 15, 2019
Essie is torn when Frankie returns wanting to take Isla home, Ric is caught between Serena and top neurosurgeon Max McGerry as they clash over his treatment options, and Jac returns from holiday and wastes no time in winding up a stressed Kian.
21x43 - Promise
October 22, 2019
Max performs dangerous brain surgery on Ric, who must confront his own mortality. Dom is shocked when Helen returns to Holby and Lofty finds out she’s pregnant.
21x44 - Hubble Bubble
October 29, 2019
It’s Halloween and Cameron is haunted by his own ghosts. Jac receives a bombshell from Stacey, and will Dominic overstep the mark when it comes to Lofty’s baby?
21x45 - Remember, Remember
November 5, 2019
In Holby City’s 1,000th episode, Jac is due to perform a milestone surgery, but will personal issues cloud her judgement? It’s Holby City Hospital’s 150th birthday and a familiar face returns for Fletch’s VIP celebration, but why are they really here? Ric is discharged from hospital, but is this the last Holby will ever see of the legendary surgeon?
21x46 - Sandra's Choice
November 12, 2019
As Elliot’s concern for Jac grows, will he ever be able to tell her his secret? Lofty is determined to be there for his new family, but will it be smooth sailing from here? Sacha is conflicted when his feelings for Essie resurface.
21x47 - We Are All the Stars
November 19, 2019
A heartbroken Lofty and Helen are rocked by tragic news which tears their world apart. A guilty Xavier evaluates his working relationship with Donna, and are the cards stacked against Jac at Darwin’s mortality and morbidity review?
21x48 - Blurring the Lines
November 26, 2019
Kian is desperate to deliver the surgery that Bea desires, but stressed Jac won’t play ball. How much will Kian sacrifice to give Bea what she wants? Dom and Lofty are too busy putting others first and not dealing with their own problems. Is their relationship strong enough to survive these tough times? Donna distracts herself by focusing on returning patient Cherie Grimes. But when fun-loving Cherie goes missing, will Donna be brave enough to convince them both to face their fears?
21x49 - Bell Jar
December 3, 2019
Elliot needs life-saving surgery. Jac is the only one qualified to do it, but will her struggles with anxiety result in her killing her mentor? Cameron sees an opportunity to make amends for past actions, but does so by manipulating a patient’s relative for his own ends. Still struggling with grief, Dom and Lofty are thrown when Carole returns from holiday blissfully unaware of their loss. Will she bring them together or only drive them further apart?
21x50 - Kintsugi
December 10, 2019
Jac has to face some home truths in the Psychiatric Unit when she's visited by the three wise men. Chloe gets some life-changing news that she has to share with Evan's sister, Phoebe. Xav and Cameron battle to save the life of a young stab victim, but they soon discover that the girl isn't as innocent as she seems when her mother turns up.
21x51 - Lemons
December 17, 2019
On the day he and Dom are due to renew their wedding vows, Lofty finally makes a decision about what he really wants in life. A newly pregnant Chloe wrestles with her conscience, and Sacha attempts put himself first, which means he has to say no to hosting Christmas with Essie.
21x52 - Be True, Be Brave, Be Kind
December 19, 2019
When Bea requires emergency surgery, a suspended Kian takes matters into his own hands, but at what cost? Essie’s feathers are ruffled by a flash new consultant, and how will Dominic react to an unwanted Christmas gift?
21x53 - Mothers and Their Daughters
December 31, 2019
Confronted with an unwelcome patient, Serena is forced to make a life or death choice. Chloe decides she’s ready to move on in 2020, but will her decision hurt a good friend? And Ange and Fletch plan their first New Year’s Eve together, but will Sacha and Dominic’s interference scupper their plans?

21x1 - Everything Old Is New Again

21x2 - China Crisis

21x3 - The Burden of Proof

21x4 - A Daring Adventure or Nothing at All

21x5 - Mad as Hell

21x6 - Force Majeure

21x7 - Good Side

21x8 - Never Say Never

21x9 - Guts

21x10 - Powerless

21x11 - A Simple Lie, Part 1

21x12 - A Simple Lie, Part Two

21x13 - Running

21x14 - Ask No Questions

21x15 - The Family Way

21x16 - North and South

21x17 - Pleased to Meet You

21x18 - Vinegar and Honey

21x19 - Ex Marks the Spot

21x20 - The Wrong Horse

21x21 - Unredeemed

21x22 - Bloodline

21x23 - In the Right Place

21x24 - Over My Dead Body

21x25 - Pigeon

21x26 - Kiss Kiss

21x27 - Flying Solo

21x28 - Reckless

21x29 - Honeymoon

21x30 - Don't Leave Me

21x31 - Things My Mother Told Me

21x32 - When Worlds Collide

21x33 - Work-Life Balance

21x34 - Where Does It Hurt?

21x35 - Babysitters and Bystanders

21x36 - The Perfect Storm

21x37 - Gods and Monsters

21x38 - Circle of Life

21x39 - Retreat

21x40 - Divine Justice

21x41 - This Be the Verse

21x42 - Hope is a Powerful Drug

21x43 - Promise

21x44 - Hubble Bubble

21x45 - Remember, Remember

21x46 - Sandra's Choice

21x47 - We Are All the Stars

21x48 - Blurring the Lines

21x49 - Bell Jar

21x50 - Kintsugi

21x51 - Lemons

21x52 - Be True, Be Brave, Be Kind

21x53 - Mothers and Their Daughters

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