4x1 - Al Sharpton, Kenny Mayne

January 3, 2006

4x2 - Carmen Electra, Autolux

January 4, 2006

4x3 - John Mayer Trio

January 5, 2006

4x4 - Cheryl Hines, David Banner

January 6, 2006

4x5 - Dominic Monaghan, Lil' Wayne

January 9, 2006

4x6 - Quentin Tarantino, Tia Carrere, John Daly

January 10, 2006

4x7 - David Boreanaz, Henry Phillips

January 11, 2006

4x8 - Evangeline Lilly, Jonathan Rhys-Meyers, Giant Drag

January 13, 2006

4x9 - John Mayer Trio, Steve-O

January 16, 2006

4x10 - Michael Chiklis, Roselyn Sanchez, Bo Bice

January 17, 2006

4x11 - Adewale Akinnuoye-Agbaje, Drew Lachey, Chamillionaire ft. Lil' Flip

January 18, 2006

4x12 - Method Man, Motion City Soundtrack, Jerry Bruckheimer

January 20, 2006

4x13 - David Gest, Feist

January 23, 2006

4x14 - Regis Philbin, Jordana Brewster, She Wants Revenge

January 24, 2006

4x15 - Jerry Rice, Mike Epps, Mike O'Connell

January 25, 2006

4x16 - Martin Lawrence, Dem Franchize Boyz ft. Bow Wow, Jermaine Dupri

January 27, 2006

4x17 - Kid Rock, David Alan Grier

January 31, 2006

4x18 - David Spade, Rob Schneider, Jon Heder, Dwele

February 1, 2006

4x19 - Michael Irvin, Jeff Daniels, The Four Tops, Buddy Guy

February 2, 2006

4x20 - Jessica Alba, Anthony Anderson, The Four Tops

February 3, 2006

4x21 - SuperBowl Episode

February 5, 2006

4x22 - Mischa Barton, Travis Barker & Shanna Moakler, James Blunt

February 6, 2006

4x23 - Jorge Garcia, Dan Naturman, Nelly

February 7, 2006

4x25 - Nick Cannon, Kathy Griffin, Damian Marley

February 9, 2006

4x26 - Steve Coogan, Travis Stork, Daddy Yankee

February 10, 2006

4x27 - Freddie Prinze, Jr., John Daly, Jacks Mannequin

February 13, 2006

4x28 - Flavor Flav

February 14, 2006

4x29 - Fred Savage, Harold Perrineau Jr., Yellowcard

February 15, 2006

4x30 - Jack Osbourne, Carolyn Murphy, Dem Franchize Boyz

February 16, 2006

4x31 - Shaun White, Steve Harvey, Hawthorne Heights

February 17, 2006

4x32 - Kathie Lee Gifford, Yehya Mohamed, Augustana

February 21, 2006

4x33 - Simon Cowell, Jennifer Esposito, Dilated Peoples

February 22, 2006

4x34 - Cuba Gooding Jr., Mike Birbiglia

February 23, 2006

4x35 - Paul Walker, Hannah Teter, Bow Wow, Travis Barker

February 24, 2006

4x36 - Kelly Ripa, Tracy Morgan

February 27, 2006

4x37 - Stacy Keibler, Howie Mandel, Three Six Mafia

February 28, 2006

4x38 - Jamie Oliver, Sasha Cohen, OK Go

March 1, 2006

4x39 - After the Academy Awards

March 5, 2006

On a historic night where Jimmy Kimmel has previously debuted such pieces as the I'm F@#%-ing Ben Affleck music video and Mel Gibson's The Colonel, he introduced a new star-studded video including Jimmy and 15 of the most handsome men in Hollywood who come together for the handsomest gathering ever. Jimmy also welcomed two-time Academy Award® nominee Robert Downey Jr. who presented the world premiere of the new Iron Man 2 trailer, and a musical performance by Grammy Award® winner Keith Urban. Plus special appearances by Ben Affleck, Jennifer Garner, Matthew McConaughey, Patrick Dempsey, Sting, and many more.

4x40 - Zooey Deschanel, Dave Sheridan, Panic! At the Disco

March 6, 2006

4x41 - Amanda Bynes, Chuck Lidell, Jamie Cullum

March 7, 2006

4x42 - Michael Rapaport, Elisha Cuthbert, Matisyahu

March 8, 2006

4x43 - John Lydon, Orlando Jones, Jim Gaffigan

March 10, 2006

4x44 - Ice Cube, Elantu B. Veovode, Nine Black Alps

March 13, 2006

4x45 - Adam Brody, John Cena, Juvenile featuring Galactic

March 14, 2006

Adam Brody, John Cena, Juvenile featuring Galactic is an episode from a talk show Jimmy Kimmel Live! which aired on March 14th, 2006.

4x46 - Randy Jackson, Janet Reno, Hard-Fi

March 15, 2006

4x47 - James Caan, Justin Chambers, The Tossers

March 17, 2006

4x48 - Hulk Hogan, Yunjin Kim, Harold & Darrell Allen

March 20, 2006

4x49 - George Lopez, Duane "Dog" Chapman, the Sounds

March 21, 2006

4x50 - Jamie-Lynn Sigler, Larry the Cable Guy, Gogol Bordello

March 22, 2006

4x51 - Kiefer Sutherland, Rocco DeLuca

March 24, 2006

4x52 - Seth Green, Chop from "King of Cars," Anthony Jeselnik, John Anderson

April 3, 2006

4x53 - Anthony Anderson, Pete Rose

April 4, 2006

4x54 - Carmen Electra, David Gest, People in Planes

April 5, 2006

4x55 - Tori Spelling, C. Thomas Howell, T.I.

April 7, 2006

4x56 - Rebecca Romijn, Judge Marilyn Milian, T-Pain

April 10, 2006

4x57 - Chris Matthews, Craig Bierko

April 11, 2006

4x58 - Wilmer Valderamma, Chris Elliott, The Wiggles

April 12, 2006

4x59 - Charlie Sheen, Rube Goldberg Contest winners, K.T. Tunstall

April 14, 2006

4x60 - Paula Abdul, Enrico Colantoni, Mighty Gonzalez

April 17, 2006

4x61 - Cheryl Hines, Landon Donovan, Bril

April 18, 2006

4x62 - Eva Longoria, Dick Cavett, Dresden Dolls

April 19, 2006

4x63 - Regis Philbin, Barry Watson, Mike Birbiglia

April 21, 2006

4x64 - Natasha Henstridge, Robert Wuhl, the cast of MTV's "Call to Greatness"

April 24, 2006

4x65 - LL Cool J, Robert Klein

April 25, 2006

4x66 - Guy Pearce, Ludacris, Atmosphere

April 26, 2006

4x67 - Susan Lucci, Adam Carolla, Rihanna

April 27, 2006

4x68 - Joe Gannascoli, Kellie Pickler, Adam Carolla, Godsmack

April 28, 2006

4x69 - Jenny McCarthy, Seth MacFarlane, The Cult

May 1, 2006

4x70 - Sir Ian McKellen, Jared Leto, Franz Ferdinand

May 2, 2006

4x71 - Chris O'Donnell, American Chopper Guys

May 3, 2006

4x72 - Kathie Lee Gifford, Isaiah Washington, Art Brut

May 4, 2006

4x73 - Famke Janssen, Jared Leto, 30 Seconds to Mars

May 5, 2006

4x74 - Carl Reiner, Ashley Tisdale, Ivan Kane's Royal Jelly dancers, Martin Fry

May 8, 2006