4x33 - Simon Cowell, Jennifer Esposito, Dilated Peoples

February 22, 2006

4x34 - Cuba Gooding Jr., Mike Birbiglia

February 23, 2006

4x35 - Paul Walker, Hannah Teter, Bow Wow, Travis Barker

February 24, 2006

4x36 - Kelly Ripa, Tracy Morgan

February 27, 2006

4x37 - Stacy Keibler, Howie Mandel, Three Six Mafia

February 28, 2006

4x38 - Jamie Oliver, Sasha Cohen, OK Go

March 1, 2006

4x39 - After the Academy Awards

March 5, 2006

On a historic night where Jimmy Kimmel has previously debuted such pieces as the I'm F@#%-ing Ben Affleck music video and Mel Gibson's The Colonel, he introduced a new star-studded video including Jimmy and 15 of the most handsome men in Hollywood who come together for the handsomest gathering ever. Jimmy also welcomed two-time Academy Award® nominee Robert Downey Jr. who presented the world premiere of the new Iron Man 2 trailer, and a musical performance by Grammy Award® winner Keith Urban. Plus special appearances by Ben Affleck, Jennifer Garner, Matthew McConaughey, Patrick Dempsey, Sting, and many more.

4x40 - Zooey Deschanel, Dave Sheridan, Panic! At the Disco

March 6, 2006

4x41 - Amanda Bynes, Chuck Lidell, Jamie Cullum

March 7, 2006

4x42 - Michael Rapaport, Elisha Cuthbert, Matisyahu

March 8, 2006

4x43 - John Lydon, Orlando Jones, Jim Gaffigan

March 10, 2006

4x44 - Ice Cube, Elantu B. Veovode, Nine Black Alps

March 13, 2006

4x45 - Adam Brody, John Cena, Juvenile featuring Galactic

March 14, 2006

Adam Brody, John Cena, Juvenile featuring Galactic is an episode from a talk show Jimmy Kimmel Live! which aired on March 14th, 2006.

4x46 - Randy Jackson, Janet Reno, Hard-Fi

March 15, 2006

4x47 - James Caan, Justin Chambers, The Tossers

March 17, 2006

4x48 - Hulk Hogan, Yunjin Kim, Harold & Darrell Allen

March 20, 2006

4x49 - George Lopez, Duane "Dog" Chapman, the Sounds

March 21, 2006

4x50 - Jamie-Lynn Sigler, Larry the Cable Guy, Gogol Bordello

March 22, 2006

4x51 - Kiefer Sutherland, Rocco DeLuca

March 24, 2006

4x52 - Seth Green, Chop from "King of Cars," Anthony Jeselnik, John Anderson

April 3, 2006

4x53 - Anthony Anderson, Pete Rose

April 4, 2006

4x54 - Carmen Electra, David Gest, People in Planes

April 5, 2006

4x55 - Tori Spelling, C. Thomas Howell, T.I.

April 7, 2006

4x56 - Rebecca Romijn, Judge Marilyn Milian, T-Pain

April 10, 2006

4x57 - Chris Matthews, Craig Bierko

April 11, 2006

4x58 - Wilmer Valderamma, Chris Elliott, The Wiggles

April 12, 2006

4x59 - Charlie Sheen, Rube Goldberg Contest winners, K.T. Tunstall

April 14, 2006

4x60 - Paula Abdul, Enrico Colantoni, Mighty Gonzalez

April 17, 2006

4x61 - Cheryl Hines, Landon Donovan, Bril

April 18, 2006

4x62 - Eva Longoria, Dick Cavett, Dresden Dolls

April 19, 2006

4x63 - Regis Philbin, Barry Watson, Mike Birbiglia

April 21, 2006

4x64 - Natasha Henstridge, Robert Wuhl, the cast of MTV's "Call to Greatness"

April 24, 2006

4x65 - LL Cool J, Robert Klein

April 25, 2006

4x66 - Guy Pearce, Ludacris, Atmosphere

April 26, 2006

4x67 - Susan Lucci, Adam Carolla, Rihanna

April 27, 2006

4x68 - Joe Gannascoli, Kellie Pickler, Adam Carolla, Godsmack

April 28, 2006

4x69 - Jenny McCarthy, Seth MacFarlane, The Cult

May 1, 2006

4x70 - Sir Ian McKellen, Jared Leto, Franz Ferdinand

May 2, 2006

4x71 - Chris O'Donnell, American Chopper Guys

May 3, 2006

4x72 - Kathie Lee Gifford, Isaiah Washington, Art Brut

May 4, 2006

4x73 - Famke Janssen, Jared Leto, 30 Seconds to Mars

May 5, 2006

4x74 - Carl Reiner, Ashley Tisdale, Ivan Kane's Royal Jelly dancers, Martin Fry

May 8, 2006

4x75 - Reggie Bush, Pat O'Brien, Lacuna Coil

May 9, 2006

4x76 - Jamie Kennedy, Daryl Hannah, Jonathan Rice

May 10, 2006

4x77 - Rev. Jesse Jackson, Jimmy Bennett, Nick Lachey

May 11, 2006

4x78 - Dominic Monaghan, J.J. Abrams, Taking Back Sunday

May 12, 2006

4x79 - Katherine Heigl, James Pickens Jr., Chandra Wilson, Ben Lee

May 15, 2006

4x80 - Drew Carey, Malcolm David Kelley, Christina Milian

May 17, 2006

4x81 - Teri Hatcher, Umphrey's McGee featuring Huey Lewis

May 18, 2006

4x82 - Sarah Silverman, Artie Lange, Hoobastank

May 19, 2006

4x84 - Julia Stiles, Jason Ritter, Atreyu

May 23, 2006

4x85 - Jon Favreau, Mike Iaconelli, Elefant

May 24, 2006

4x86 - Dane Cook, Brett Ratner

May 26, 2006

4x87 - Ice Cube, Paget Brewster

June 6, 2006

4x88 - Jessica Alba, Larry the Cable Guy, Him

June 7, 2006

4x89 - Rosie Perez, Jared Hess, Elefant

June 8, 2006

4x90 - John C. Reilly, Gary Gulman

June 9, 2006

4x91 - Jaime Pressly, Xzibit, The Streets

June 13, 2006

4x92 - Luke Perry, Jean Smart, Huey Lewis

June 14, 2006

4x93 - Jack Black, Wolfmother

June 15, 2006

4x94 - Fiona Apple

June 16, 2006

4x95 - Ozzy Osbourne, Anthony Bourdain

June 20, 2006

4x96 - Bonnie Hunt, Phil Gordon, Buckcherry

June 21, 2006

4x97 - Geena Davis, Louis C.K., Jeff Corwin

June 22, 2006

4x98 - Mariah Carey, Rob Zombie

June 23, 2006

4x99 - Jason Alexander, Meagan Good, Jamie Kennedy

June 26, 2006

4x100 - Tommy Lee, 98-year-old high school student Josephine Belasco, Greg Fitzsimmons, the Fixx

June 27, 2006

4x101 - George Foreman, psychotherapist Richard Cohen, Blue October

June 28, 2006

4x102 - Kathy Griffin, Jason Gray-Stanford, the Brand New Heavies

June 30, 2006

4x103 - Ed Burns, NBA Finals MVP Dwayne Wade, Flyleaf

July 10, 2006

4x104 - Tracy Morgan, Shaun Alexander, Sonic Youth

July 11, 2006

4x105 - Lance Armstrong, Matt Dallas, Smoosh

July 12, 2006

4x106 - Brittany Murphy, Danica Patrick, Eagles of Death Metal

July 14, 2006

4x107 - Terrell Owens, Rainn Wilson, Rascal Flatts

July 17, 2006

4x108 - Shawn & Marlon Wayans, Fred Willard, Korn

July 18, 2006

4x109 - Robin Williams, Anna Faris, Rhymefest

July 19, 2006

4x110 - Allison Janney, Morgan Spurlock, Jurassic 5

July 21, 2006

4x111 - Rosario Dawson, Jesse Metcalf, the Flaming Lips

July 24, 2006

4x112 - Gene Simmons, Jeff Ross, the Elected

July 25, 2006

4x113 - Jon Cryer, the Dudesons, Los Lonely Boys

July 26, 2006

4x114 - Regis Philbin, Trevor Fehrman, Pharrell

July 28, 2006

4x115 - Flavor Flav, Leslie Bibb, Ben Harper

July 31, 2006

4x116 - Sandra Oh, Jewel

August 1, 2006

4x117 - Cheryl Hines, Shaun White, Russell Peters

August 2, 2006

4x118 - Will Ferrell, Bobby Cannavale, Under the Influence of Giants

August 4, 2006

4x119 - Matt Dillon, Justin Long, Ziggy Marley

August 14, 2006

4x120 - Jonathan Winters, Kenan Thompson, Against Me!

August 15, 2006

4x121 - Paul Reubens, snake handler Jules Sylvester, Obie Trice, Leonid "the Magnificent" Filatov

August 16, 2006

4x122 - Samuel L. Jackson, Elisha Cuthbert, Cobra Starship

August 18, 2006

4x123 - Heidi Klum, Dave Navarro, Panic Channel

August 21, 2006

4x124 - Hillary Duff, Ultimate Fighting Champion Chuck Lidell, Anti-Flag

August 22, 2006

4x125 - Tom Cavanaugh, Tommy Chong, Cartel

August 23, 2006

4x126 - Anthony Michael Hall, Joan & Melissa Rivers, the Red Jumpsuit Apparatus

August 25, 2006

4x127 - Kevin Nealon, Jay Chandrasekhar, Pat Green

August 29, 2006

4x128 - Tommy Lee, Wayne Brady, Starsailor

August 30, 2006

4x129 - Michael Rapaport, Jimmie Johnson, Jo Koy, Wayman Tisdale

September 1, 2006

4x130 - Lauren Holly, private investigator Vinny Parco, the Roots

September 5, 2006

4x131 - Ron Livingston, Toby Keith

September 6, 2006

4x132 - Anthony Michael Hall, James Carville, Robert Randolph and the Family Band

September 7, 2006

4x133 - Tyra Banks, Jason Statham, Papa Roach

September 8, 2006