4x1 - Robin Thicke

January 4, 2010

We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.

4x2 - Mary J. Blige

January 5, 2010

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

4x3 - Holly Madison

January 6, 2010

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

4x5 - Giuliana & Bill Rancic

January 11, 2010

Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.

4x6 - Aisha Tyler

January 12, 2010

We welcome back the very funny Aisha Tyler, from the new show Archer. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

4x7 - Amy Brenneman

January 13, 2010

Amy Brenneman of Private Practice stops by, perhaps with some doctorly advice. Comedian John Caparulo, comedian Jen Kirkman and comedian Dan Levy.

4x8 - Snooki, Pauly D and The Situation

January 14, 2010

Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.

4x9 - David Arquette

January 18, 2010

David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar

4x10 - Adrianne Palicki

January 19, 2010

Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.

4x11 - Kaley Cuoco

January 20, 2010

Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.

4x12 - James Van Der Beek

January 21, 2010

James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.

4x13 - Katharine McPhee

January 25, 2010

4x14 - Jill Scott

January 26, 2010

4x15 - Dax Shepard

January 27, 2010

4x16 - Staff Book Club

January 28, 2010

4x17 - Camila Alves

February 1, 2010

4x18 - Andy Whitfield

February 2, 2010

4x19 - Shorty Rossi

February 3, 2010

4x20 - Julie Benz

February 4, 2010

4x21 - Ozzy Osbourne

February 8, 2010

4x22 - Amanda Seyfried

February 9, 2010

4x23 - Dave Salmoni

February 10, 2010

We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.

4x24 - Channing Tatum

February 12, 2010

4x25 - Kate Flannery

February 15, 2010

We get down to business with The Office's Kate Flannery. Comedian Loni Love, comedian Dan Levy and comedian Whitney Cummings.

4x26 - Jackie Collins

February 16, 2010

Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.

4x27 - Lisa Edelstein

February 17, 2010

Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.

4x28 - Eli Roth

February 18, 2010

4x29 - Keshia Knight Pulliam

February 22, 2010

House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins

4x30 - Danica Patrick

February 23, 2010

We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.

4x31 - Radha Mitchell

February 24, 2010

Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.

4x32 - Parker Posey

February 25, 2010

The Chelsea Lately cast do a Kardashian skit. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

4x33 - Sean William Scott

March 1, 2010

From the new movie Cop Out we've got Seann William Scott in our custody today. Comedian Chris Hardwick and Comedians Randy and Jason Sklar.

4x34 - Kendra & Hank Baskett

March 2, 2010

Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.

4x35 - Single Staffers, Handler Edition

March 3, 2010

Please enjoy a very special Handler Edition of Single Staffers. Comedian Matt Bruanger, comedian Heather McDonald and comedian Moshe Kasher.

4x36 - Gabourey Sidibe

March 4, 2010

From Precious, the Academy Award-nominated Gabourey Sidibe is here. TV personality Ross Mathews, comedian Christina Pazsitzky and comedian Guy Branum.

4x37 - Kevin McKidd

March 8, 2010

Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.

4x38 - Chelsea Chelsea Bang Bang

March 9, 2010

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

4x39 - Amy Ryan

March 10, 2010

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

4x40 - Pretty Wild Cast

March 11, 2010

Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.

4x41 - Shenae Grimes

March 15, 2010

90210's Shenae Grimes is here to give us the deets on all things West Beverly. Comedian Bobby Lee, comedian T.J. Miller and comedian Whitney Cummings.

4x42 - Rachael Harris

March 16, 2010

From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

4x43 - Avril Lavigne

March 17, 2010

We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.

4x44 - Duane "Dog" Chapman

March 18, 2010

We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.

4x45 - Kelly Cutrone

March 22, 2010

4x46 - Scott Wolf

March 23, 2010

4x47 - Crispin Glover

March 24, 2010

4x48 - Blake Shelton

March 25, 2010

4x49 - Ludacris

March 29, 2010

Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.

4x50 - Johnny Weir

March 30, 2010

Johnny Weir is here, and unfortunately our show is not "on ice" this week. Comedian Jo Koy, comedian Lil JJ and comedian Sarah Colonna.

4x51 - Erykah Badu

March 31, 2010

4x52 - Justin Bieber

April 1, 2010

Chuy Bravo wrote a book, Little Nuggets of Wisdom, and he's here to share them. This, BTW, is all 100 percent for real, for real, girl. Comedian Heather McDonald, comedians Randy & Jason Sklar.

4x53 - Jennifer Love Hewitt

April 5, 2010

Author of The Day I Shot Cupid, Jennifer Love Hewitt is here. Comedian Brad Wollack, E!'s own Michael Yo and Comedian Mo Mandel,

4x54 - Ed Asner

April 6, 2010

Find out how spunky Chelsea can really be when TV Icon and star of Up Ed Asner stops by. Comedian Josh Wolf, comedian Loni Love and comedian Wil Anderson.