5x1 - Single Staffers: Religion Edition

January 3, 2011

Comedian Josh Wolf, comedian Margaret Cho and TV personality Ross Mathews

5x2 - Armie Hammer

January 4, 2011

Comedian Jo Koy, comedian Natasha Leggero and comedian John Caparulo

5x3 - Kevin Spacey

January 5, 2011

The incomparable Kevin Spacey is here to talk about his new film Casino Jack. Comedian Chris Franjola, comedian Whitney Cummings and E!'s own Michael Yo.

5x4 - Tim McGraw

January 6, 2011

5x5 - Sophia Bush

January 10, 2011

From One Tree Hill, Sophia Bush is here and were going to find out if she wants to be anything other than what she's been trying to be lately. Comedian Brad Wollack, actress-comedian Arden Myrin and comedian Dov Davidoff

5x6 - Zach Gilford

January 11, 2011

One of our favorite people ever Zach Gilford is here to tell us about his new show Off the Map. Comedian Jo Koy, comedian Sarah Colonna and comedian Jason Sklar

5x7 - Roseanne Barr

January 12, 2011

The unmatched Roseanne Barr is here with her new book Roseannearchy. Comedian Josh Wolf, comedian Matt Braunger and TV personality Ross Mathews

5x8 - Sara Bareilles

January 13, 2011

Sara Bareilles and her chart topping album Kaleidoscope Heart are on the show tonight. Comedian Bobby Lee, comedian Loni Love and comedian T.J. Miller

5x9 - Denis Leary

January 17, 2011

Find out what Denis Leary has going on, hint: a new comedy special, a new book and the new Spider-Man movie. Comedian Josh Wolf, comedian Natasha Leggero and comedian Jason Sklar.

5x10 - Ed Asner

January 18, 2011

5x11 - Ginnifer Goodwin

January 19, 2011

The newly engaged Ginnifer Goodwin from HBO's Big Love joins us tonight. Comedian Greg Proops, comedian Whitney Cummings, and TV personality Ross Mathews

5x12 - Matt LeBlanc

January 20, 2011

Matt LeBlanc is here to tell us about the very funny new Showtime series he stars in, Episodes. Comedian Chris Franjola, writer Diablo Cody and comedian Dan Levy

5x13 - Whitney Port

January 24, 2011

5x14 - Piers Morgan

January 25, 2011

TV host Piers Morgan on his new show, Piers Morgan Tonight; Round table discussion with comics Chris Hardwick, Rove McManus, and Jo Koy.

5x15 - Wilmer Valderrama

January 26, 2011

Actor Wilmer Valderrama on his new film, From Prada to Nada; Round table discussion with comics Gary Valentine, Ross Mathews, and Sarah Colonna.

5x16 - Taraji P. Henson

January 27, 2011

Taraji P. Henson is back and has a lot going on including the new Lifetime movie Taken From Me: the Tiffany Rubin Story. Comedian Bobby Lee, actress-comedian Arden Myrin and comedian Ben Gleib

5x17 - Kevin Smith

January 31, 2011

The headline-making director of the new film Red State, Kevin Smith is here. Comedian Brad Wollack, comedian Dov Davidoff and comedian Natasha Leggero.

5x18 - Kevin Nealon

February 1, 2011

Our good friend Kevin Nealon is here from the new movie Just Go With It. Comedian Joy Koy, E!'s own Michael Yo and comedian John Caparulo

5x19 - Rachael Bilson

February 2, 2011

Rachel Bilson is here from the new film Waiting for Forever. Comedian Bill Bellamy, comedian Whitney Cummings and comedian Chris Franjola

5x20 - Staff Football Challenge

February 3, 2011

The staff plays in a men vs. women football challenge in honor of the upcoming Superbowl. Comedian Josh Wolf, comedian Heather McDonald and comedian Lavell Crawford.

5x21 - Jennifer Aniston

February 7, 2011

Jennifer Aniston is back to tell us about her new movie Just Go With It. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Ryan Stout

5x22 - Minka Kelly

February 8, 2011

From the No. 1 movie in America The Roommate, Minka Kelly is here. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Greg Proops.

5x23 - James Blunt

February 9, 2011

James Blunt is here and he's got a new album called Some Kind of Trouble. Musician Jeff Wild, TV personality Ross Mathews and comedian Gary Valentine

5x24 - Jennifer Beals

February 10, 2011

From the new Fox drama The Chicago Code Jennifer Beals is here. Comedian Josh Wolf, comedian Loni Love and comedian Mo Mandel

5x26 - Cyndi Lauper

February 15, 2011

Fourteen-time Grammy Nominee Cyndi Lauper is here telling us about her new album, Memphis Blues. Comedian Joy Koy, comedian Fortune Feimster and comedian John Caparulo

5x27 - Lo Bosworth

February 16, 2011

Lo Bosworth, author of The Lo Down joins us tonight. Comedian Brad Wollack, comedian Natasha Leggero and comedian Wil Anderson

5x28 - Donald Schultz

February 17, 2011

Donald Schultz is back with some new animal friends. Comedian Josh Wolf, comedian Jen Kirkman and comedian Joe Matarese

5x29 - Emmy Rossum

February 21, 2011

Emmy Rossum is here from the hit Showtime series Shameless. Happy Presidents Day, girl. Comedian Dan Levy, comedian Sarah Colonna and comedian Josh Wolf

5x30 - Irina Shayk

February 22, 2011

Sports Illustrated swimsuit cover model Irina Shayk joins us tonight. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Bobby Lee

5x31 - Jason Biggs

February 23, 2011

Jason Biggs is here to tell us about his new show Mad Love. Comedian Joe DeVito, comedian Loni Love, and TV personality Ross Mathews

5x32 - Jason Sudeikis

February 24, 2011

From the very funny new film Hall Pass Jason Sudeikis is here. Comedian Chris Franjola, writer Diablo Cody and comedian Ben Gleib

5x33 - Adele

February 28, 2011

With her brilliant new album, 21, the fantastic Adele joins us tonight. Comedian Greg Fitzsimmons, comedian Heather McDonald and comedian Josh Wolf

5x34 - Lil Jon

March 1, 2011

Lil Jon, Shawty Putt and Chuy debut their new music video here tonight. Seriously. Comedian Chris Franjola, comedian Sarah Colonna and comedian Jo Koy

5x35 - Anna Faris

March 2, 2011

From the new movie Take Me Home Tonight, Anna Faris is here. Comedian Jeff Wild, comedian Natasha Leggero and TV personality Ross Mathews

5x36 - Isla Fisher

March 3, 2011

Isla Fisher is here from the new film Rango. Comedian Brad Wollack, comedian Fortune Feimster and comedian Gary Valentine

5x37 - Sophie Monk

March 7, 2011

We kick things off things in Australia with one of their faves, Sophie Monk. Comedian Chris Franjola, comedian Heather McDonald and comedian Celia Pacquola.

5x38 - Henry Rollins

March 8, 2011

Musician Henry Rollins. Comedian Brad Wollack, comedian Heather McDonald and comedian Adam Richard

5x39 - Nick De Vos

March 9, 2011

Zookeeper Nick De Vos is here tonight with some of his Australian animal friends. Comedian Jeff Wild, comedian Sarah Colonna and comedian Chris Franjola

5x40 - Rihanna

March 10, 2011

Look who we ran into Down Under...Rihanna joins the show tonight. Comedian Josh Wolf, comedian Fortune Feimster and comedian Adam Hills

5x41 - Avril Lavigne

March 21, 2011

Singer Avril Lavigne on her new album, Goodbye Lullaby; Round table discussion with comics Brad Wollack, Natasha Leggero, and Matt Braunger.

5x42 - Vera Wang

March 22, 2011

Designer Vera Wang on her new fragrance, Preppy Princess; Round table discussion with comics Chris Hardwick, Jo Koy, and Sarah Colonna.

5x43 - Carla Gugino

March 23, 2011

Actress Carla Gugino on her new film, Elektra Luxx; Round table discussion with comics Chris Franjola, Loni Love, and Greg Proops.

5x44 - Brittany Snow

March 24, 2011

Brittany Snow from Harry's Law and the cover of Maxim joins us tonight. Comedian Jim Norton, comedian Jen Kirkman and TV personality Ross Mathews

5x45 - Mireya Mayor

March 28, 2011

Author of Pink Boots and a Machete, National Geographic's Mireya Mayor is here with some animal friends. Comedian Ben Gleib, comedian Fortune Feimster and comedian Josh Wolf.

5x46 - Blake Shelton

March 29, 2011

Tonight we gladly welcome back country superstar Blake Shelton. E!'s own Michael Yo, comedian Heather McDonald and comedian Jo Koy

5x47 - Jerry Weintraub

March 30, 2011

Legendary film producer and Jew Jerry Weintraub is here with his documentary, His Way. Comedian Joe Matarese, actress-comedian Arden Myrin and comedian John Caparulo

5x48 - Shenae Grimes

March 31, 2011

From Scream 4 Shenae Grimes is on the show tonight. Comedian Dov Davidoff, comedian Dan Levy and TV personality Ross Mathews

5x49 - James Marsden

April 4, 2011

From the No. 1 film Hop, James Marsden joins us tonight. Comedian Brad Wollack, writer Diablo Cody and comedian Gary Valentine

5x50 - Mark Macdonald

April 5, 2011

Nutritionist and author or Body Confidence Mark Macdonald is here. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Matt Braunger

5x51 - Zooey Deschanel

April 6, 2011

Zooey Deschanel is here telling us about her new movie, Your Highness. Comedian Josh Wolf, comedian Erin Gibson and comedian Jo Koy

5x52 - Elizabeth Berkley

April 7, 2011

Actress Elizabeth Berkley is here with her new book Ask Elizabeth. Comedian Chris Franjola, comedian Jeff Wild and TV personality Ross Mathews

5x53 - Joshua Jackson

April 11, 2011

Anything can happen with Fringe's Joshua Jackson on the show tonight. Comedian Bobby Lee, comedian Heather McDonald and comedian Ryan Stout

5x54 - Adam Brody

April 12, 2011

Find out if Adam Brody lives of dies in Scream 4 tonight. Comedian Bill Bellamy, actress-comedian Arden Myrin and comedian Josh Wolf

5x55 - JoAnna Garcia Swisher

April 13, 2011

JoAnna Garcia Swisher from Better With You joins us tonight. Comedian John Caparulo, comedian Jen Kirkman and comedian Greg Fitzsimmons

5x56 - Hayden Panettiere

April 14, 2011

Want to go double or nothing (see Tuesday) on Hayden Panettiere living or dying in Scream 4? Comedian Fortune Feimster, comedian Natasha Leggero and comedian Sarah Colonna

5x57 - Robin Wright

April 18, 2011

From the new film The Conspirator Robin Wright is here. Comedian Josh Wolf, comedian Natasha Leggero and comedian Michael Yo

5x58 - Simon LeBon & John Taylor

April 19, 2011

From Duran Duran Simon LeBon and Nick Rhodes are here to talk their latest CD All You Need Is Now. Comedian Ben Gleib, comedian Brad Wollack and comedian Jo Koy

5x59 - Ziggy Marley

April 20, 2011

Ziggy Marley tells us about his new comic book Marijuanaman tonight. Comedian Lavell Crawford, comedian Heather McDonald, and TV personality Ross Mathews

5x60 - Malin Akerman

April 21, 2011

The very Swedish Malin Akerman is here tonight with her new movie The Bang Bang Club. Comedian Chris Franjola, comedian Loni Love and comedian Chris Hardwick

5x61 - Gwyneth Paltrow

April 25, 2011

Gwyneth Paltrow is on the show tonight with her new book My Father's Daughter. Comedian Dan Levy, comedian-actress Arden Myrin and comedian Bobby Lee

5x62 - Taylor Momsen

April 26, 2011

The Pretty Reckless' Taylor Momsen talks Gossip Girl and her album Light Me Up. Comedian John Caparulo, comedian Sarah Colonna and comedian Jo Koy

5x63 - Jason Priestley

April 27, 2011

Comedian Matt Braunger, comedian Jen Kirkman and comedian T.J. Miller

5x64 - Mary McCormack

April 28, 2011

From In Plain Sight, our good friend Mary McCormack is here. Comedian Fortune Feimster, comedian Gary Valentine and TV personality Ross Mathews

5x65 - Tyrese Gibson

May 2, 2011

Tyrese Gibson, from the No. 1 movie in America, Fast Five, is on the show tonight. Comedian Josh Wolf, comedian Heather McDonald and comedian Brad Wollack

5x66 - Paula Patton

May 3, 2011

From the new film Jumping the Broom the delightful Paula Patton is here. Comedian Chris Hardwick, comedian Loni Love and comedian Jo Koy

5x67 - Melissa McCarthy

May 4, 2011

Melissa McCarthy is here from the very funny new movie Bridesmaids. Comedian Joe Matarese, comedian Chris Franjola and TV personality Ross Mathews

5x68 - Dita Von Teese

May 5, 2011

Dita Von Teese is here to fill us in on her latest endeavors including her MargaDita. Comedian Fortune Feimster, comedian John Caparulo and comedian Greg Fitzsimmons

5x69 - Will Ferrell

May 9, 2011

From the new film Everything Must Go, Will Ferrell is here tonight. Comedian Jen Kirkman, comedian Whitney Cummings and comedian Jo Koy

5x70 - Paul Bettany

May 10, 2011

Paul Bettany shows us he's an action star in his new film Priest tonight. Comedian Jeff Wild, comedian Sarah Colonna and comedian Chris Franjola

5x71 - Judd Apatow

May 12, 2011

Judd Apatow is here to tell us about his new film Bridesmaids. Comedian Jim Norton, comedian Natasha Leggero and comedian Josh Wolf.

5x72 - Kelly Osbourne

May 16, 2011

One of the hosts of E!'s Fashion Police Kelly Osbourne is on the show tonight. Comedian Fortune Feimster, comedian John Caparulo and comedian Loni Love

5x73 - Kellan Lutz

May 17, 2011

Kellan Lutz is here with his new film Love, Wedding, Marriage. Comedian Greg Proops, comedian Heather McDonald and comedian Jo Koy

5x74 - Maya Rudolph

May 18, 2011

From the very funny film Bridesmaids. Maya Rudolph is here. Comedian Josh Wolf, comedian Mo Mandel and TV personality Ross Mathews

5x75 - Lucy Liu

May 19, 2011

We gladly welcome back Lucy Liu, star of Kung Fu Panda 2, to the show. Comedian Brad Wollack, actress-comedian Arden Myrin and E! News' Michael Yo