4x91 - Denis Leary

June 14, 2010

Star of all things Rescue Me the hilarious Denis Leary is here. Comedian Steve Marmalstein, comedian Natasha Leggero and TV personality Ross Mathews.

4x92 - Sarah McLachlan

June 15, 2010

We're getting a little Lilith tonight when Sarah McLachlan stops by and talks her new album, Laws of Illusion. Comedian Jo Koy, E!'s own Michael Yo and comedian Sarah Colonna.

4x93 - Lil Jon

June 16, 2010

We're getting crunk with Lil Jon and his new album Crunk Rock…YEAAAAHHHH! Comedian John Caparulo, comedian Christina Pazsitzky and comedian Josh Wolf.

4x94 - Roy Handler & Charley

June 17, 2010

Learn how to make cupcakes with Roy and Charley tonight. Comedian Brad Wollack, comedian Dan Levy and comedian Bobby Lee.

4x95 - A.J. Khubani

June 21, 2010

Learn about the borderline amazing new As Seen on TV Products with A.J. Khubani. Comedian Chris Franjola, comedian Whitney Cummings and comedian Finesse Mitchell.

4x96 - Mary McCormack

June 22, 2010

Star of In Plain Sight Mary McCormack graces us with her presence. Comedian Joe DeRosa, comedian Heather McDonald and comedian Josh Wolf.

4x97 - Ron Artest

June 23, 2010

Comedian Matt Braunger, comedian Moshe Kasher and comedian Guy Branum. Lakers champ Ron Artest tries to get into Chelsea's pants and chats about his NBA win. Plus, hear about his budding music career!

4x98 - Ashley Greene

June 24, 2010

Actress Ashley Greene on her new movie, "The Twilight Saga: Eclipse"; Round table discussion with comics Mo Mandel, Arden Myrin, and Ross Mathews.

4x99 - T.I.

June 28, 2010

Rapper T.I. on his new album, "King Uncaged"; Round table discussion with comics Sarah Colonna, Jamie Kaler, and Josh Wolf.

4x100 - Bryce Dallas Howard

June 29, 2010

From the most-anticipated movie in the country, Eclipse, Bryce Dallas Howard is here. Comedian Brad Wollack, comedian John Caparulo and comedian Christina Pazsitzky

4x101 - Joe's Crab Shack

June 30, 2010

Check out Chuy as the new spokesperson for Joe's Crab Shack...You're welcome crabs. Comedian Bobby Lee, comedian Jo Koy and comedian Ben Gleib

4x102 - Sam Trammell

July 1, 2010

True Blood's favorite shapeshifter Sam Trammell is back. Comedian Bobby Lee, comedian Jo Koy and comedian Ben Gleib

4x103 - Claire Smith

July 5, 2010

Learn about the summer's best drinks with Belvedere's Claire Smith. Comedian Jason Sklar, comedian Natasha Leggero and comedian Gary Valentine

4x104 - Pharrell

July 6, 2010

Pharrell does a lot, like producing the soundtrack and composing the score for Despicable Me. Comedian Jo Koy, comedian Whitney Cummings and TV personality Ross Mathews.

4x105 - Kristin Cavallari

July 8, 2010

Kristin Cavallari is here and has all the info you're dying to know about the final season of The Hills. Comedian Chris Hardwick, comedian Heather McDonald and comedian Dov Davidoff

4x106 - Dave Salmoni

July 19, 2010

Canadian animal trainer Dave Salmoni on his new show, "Savaged with Dave Salmoni"; Round table discussion with comics Jason Sklar, Natasha Leggero, and Gary Valentine.

4x107 - Susan Sarandon

July 20, 2010

Actress Susan Sarandon on her upcoming reality ping-pong series; Round table discussion with comics Jo Koy, Ben Gleib, and Brad Wollack.

4x108 - Anna Paquin

July 21, 2010

Sink your teeth into this: tonight we welcome Anna Paquin from HBO's True Blood. Rapper Lil John, rapper Big Boi and rapper Rick Ross.

4x109 - Arsenio Hall

July 22, 2010

Dust off your fists, girls, because Arsenio Hall is in the house. Comedian Chris Franjola, comedian Christina Pazsitzky and TV personality Ross Mathews

4x110 - Frank Grillo

July 26, 2010

Actor Frank Grillo on his show, "The Gates"; Round table discussion with comics Loni Love, Josh Wolf, and Greg Proops.

4x111 - Kathy Griffin

July 27, 2010

Comedian Kathy Griffin on her show, "Kathy Griffin: My Life on the D-List"; Round table discussion with comics Jo Koy, Michael Yo, and Whitney Cummings.

4x112 - Chicken Charlie

July 28, 2010

Fry cook Chicken Charlie discusses frying food; Round table discussion with comics Chris Hardwick, Heather McDonald, and Rove McManus.

4x113 - Ron Livingston

July 29, 2010

Actor Ron Livingston on his new film, "Dinner with Schmucks"; Round table discussion with comics Ross Mathews, Sarah Colonna, Guy Branum.

4x114 - Gabrielle Reece

August 2, 2010

Tonight's guest is volleyball pro Gabby Reece. At the Round Table: John Caparulo, Christina Pazsitzky, Matt Braunger.

4x115 - Lisa Lampanelli

August 3, 2010

Tonight's guest is actress Lisa Lampanelli. At the Round Table: Brad Wollack, Jo Koy, James Van Praagh.

4x116 - Fat Joe

August 4, 2010

Fat Joe returns with his new album, The Darkside. Comedian Chris Franjola, actress-comedian Arden Myrin and TV personality Ross Mathews

4x117 - Eva Mendes

August 5, 2010

From The Other Guys, Eva Mendes is here. Comedian Dan Levy, comedian Natasha Leggero and comedian Ben Gleib.

4x118 - Bethenny Frankel

August 9, 2010

Star of Bravo's Bethenny Getting Married?, Bethenny Frankel is here. Comedian Josh Wolf, comedian Whitney Cummings and comedian Guy Branum

4x119 - Margaret Cho

August 10, 2010

Margaret Cho tells us about her new comedy/music album Cho Dependent. Comedian Heather McDonald, comedian Hyla Mathews and TV personality Ross Mathews.

4x120 - Alanis Morissette

August 11, 2010

We're checking in with Alanis Morissette who's working her acting chops on the new season of Weeds. Comedian Bobby Lee, comedian Loni Love and comedian Dov Davidoff.

4x121 - Extra Round Table

August 12, 2010

Extra Round Table. Comedian Jo Koy, comedian Sarah Colonna and comedian Jason Sklar

4x122 - Kim Raver

August 16, 2010

Grey's Anatomy star Kim Raver tells us about her foray into the Lifetime TV movie, Bond of Silence. Comedian Finesse Mitchell, actress-comedian Arden Myrin, and TV personality Ross Mathews

4x123 - Kim & Kourtney Kardashian

August 17, 2010

Kim and Kourtney Kardashian are here to make sure everyone is still Keeping Up With the Kardashians. Comedian Bill Bellamy, comedian Natasha Leggero and comedian Josh Wolf.

4x124 - Jennifer Aniston

August 18, 2010

Jennifer Aniston is here telling us about her new film The Switch. Comedian John Caparulo, comedian Whitney Cummings and comedian Brad Wollack.

4x125 - Elisabeth Shue

August 19, 2010

From the most frightening 3D movie of the summer, Piranha: 3D, Elisabeth Shue is here. Comedian Chris Franjola, comedian Owen Benjamin and comedian Jo Koy

4x126 - Eli Roth

August 23, 2010

Eli Roth tells us about his latest film The Last Exorcism. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Gary Valentine.

4x127 - Rufus Wainwright

August 24, 2010

Rufus Wainwright tells us about his tour and latest CD, All Days are Nights: Songs for Lulu. Comedian Josh Wolf, comedian Heather McDonald and musician Jeff Wild.

4x128 - Jerry Springer

August 25, 2010

Jerry Springer tells us about his foray into game shows as host of GSN's Baggage. Comedian Randy Sklar, comedian Christina Pazsitzky and comedian Guy Branum.

4x129 - Angie Harmon

August 26, 2010

Angie Harmon tells us about her hugely popular show Rizzoli & Isles. Comedian Ben Gleib, comedian Godfrey and comedian Jo Koy

4x130 - Jewel

August 30, 2010

Jewel returns and tells us about her new album, Sweet and Wild. Comedian Brad Wollack, comedian Natasha Leggero and comedian Steve Marmalstein.

4x131 - Louise Roe

August 31, 2010

Host of CW's Plain Jane Louise Roe is here to make over the staff of Chelsea Lately. Comedian Josh Wolf, comedian John Caparulo and musician Jo Koy.

4x132 - Extra Roundtable

September 1, 2010

You asked for more round table, tonight you're getting more round table. You're welcome, America. Comedian Chris Franjola, comedian Loni Love and comedian Joe DeRosa

4x133 - Mel B

September 2, 2010

Mel B. tells us about her new Style Network show Mel B: It's a Scary Life. Comedian Greg Proops, actress-comedian Arden Myrin and comedian-host Rove McManus.

4x134 - Ne-Yo

September 6, 2010

R&B singer Ne-Yo on his new album, "Libra Scale "; Round table discussion with comics Michael Yo, Jen Kirkman, and Ross Mathews.

4x135 - B.o.B.

September 7, 2010

VMA performer and five-time nominee B.o.B is here with his No. 1 album B.o.B Presents: The Adventures of Bobby Ray. Comedian Matt Braunger, comedian Heather McDonald and comedian Josh Wolf.

4x136 - Extra Roundtable

September 8, 2010

An extra-long Round Table. You're welcome, America. Comedian T. J. Miller, comedian Sarah Colonna and comedian Dov Davidoff.

4x137 - Extra Roundtable

September 9, 2010

An extra-long Round Table. You're welcome, America. Comedian Ben Gleib, actress-comedian Whitney Cummings and comedian Jo Koy.

4x138 - Emma Stone

September 13, 2010

From Easy A, the can-do-no-wrong-in-my-book Emma Stone is here. Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Kevin Hart.

4x139 - Snooki and Pauly D

September 14, 2010

Get ready to GTL because Jersey Shore's Snooki and Pauly D are back. Comedian Donnell Rawlings, comedian Natasha Leggero and comedian Brad Wollack.

4x140 - Usher

September 15, 2010

Usher has a new album, Versus, is on tour and is hanging out with us tonight, everyone rejoice. Comedian Loni Love, comedian Chris Franjola and musician Jeff Wild.

4x142 - Meghan McCain

September 20, 2010

We welcome author of Dirty Sexy Politics, Meghan McCain. Comedian Josh Wolf, comedian Heather McDonald and comedian Gary Valentine.

4x143 - Emily Rose

September 21, 2010

Emily Rose from SyFy's Haven is here. Comedian Matt Braunger, comedian Sarah Colonna and comedian Mo Mandel.

4x144 - Laird Hamilton

September 22, 2010

We're pretty stoked that world-renowned surfer Laird Hamilton returns tonight. Comedian Jason Sklar, comedian Michelle Collins and comedian Jo Koy.

4x145 - Kristen Bell

September 23, 2010

From the hilarious movie You Again, Jersey Shore's No. 1 fan Kristen Bell is here. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews.

4x146 - Adam Levine

September 27, 2010

Adam Levine of Maroon 5 is here with their new album Hands All Over. Comedian Brad Wollack, comedian John Caparulo and writer Diablo Cody.

4x147 - Taye Diggs

September 28, 2010

Star of Private Practice Taye Diggs is here…he may or may not be wearing a shirt. Comedian Jo Koy, comedian Dov Davidoff and comedian Natasha Leggero.

4x148 - Dax Shepard

September 29, 2010

Parenthood's Dax Shepard is here to discuss many a things, one being his new film The Freebie. Comedian Chris Franjola, comedian Dan Levy and TV personality Ross Mathews.

4x149 - AnnaLynne McCord

September 30, 2010

AnnaLynne McCord is here to give us the 411 on all things 90210. Comedian Chris Hardwick, comedian Ben Gleib and actress-comedian Arden Myrin.

4x150 - Duane "Dog" Chapman, Beth Smith Chapman,

October 4, 2010

Dog the Bounty Hunter's Beth and Duane "Dog" Chapman grace our stage tonight. Comedian Moshe Kasher, comedian Heather McDonald and comedian Josh Wolf.

4x151 - Tommy Lee

October 5, 2010

Tommy Lee is here with his latest Methods of Mayhem project A Public Disservice Announcement. TV personality Ross Mathews, comedian Whitney Cummings and comedian Guy Branum.

4x152 - Kelly Osbourne

October 6, 2010

Cohost of E!'s Fashion Police, Kelly Osbourne, is here. Comedian Jo Koy, comedian Randy Sklar and comedian Loni Love.

4x153 - Trace Adkins

October 11, 2010

The cowboy himself, Trace Adkins, is back with his new album Cowboy's Back in Town. Comedian Brad Wollack, comedian Chris Hardwick and comedian Natasha Leggero.

4x154 - Leah Remini

October 12, 2010

Cohost of the new CBS talk show The Talk, Leah Remini is here. Comedian Jo Koy, comedian Sarah Colonna and comedian Greg Proops.

4x155 - Lauren Conrad

October 13, 2010

Author of Sugar and Spice and Lauren Conrad Style the very busy Lauren Conrad is here. Comedian John Caparulo, comedian Josh Wolf and comedian Jim Breuer.

4x156 - Amy Brenneman

October 14, 2010

From Private Practice, the delightful Amy Brenneman returns to the show tonight. Comedian Chris Franjola, actress-comedian Arden Myrin and comedian Kevin Hart.

4x157 - Johnny Knoxville

October 18, 2010

The biggest jackass of them all, Johnny Knoxville from Jackass 3D is here. Comedian Ben Gleib, comedian Loni Love and TV personality Ross Mathews.

4x158 - Blake Shelton

October 19, 2010

The newest member of the Grand Ole Opry, Blake Shelton is here with his new album All About Tonight. Comedian Jo Koy, comedian Heather McDonald and E!'s own Michael Yo.

4x159 - Lloyd Banks

October 20, 2010

Rapper Lloyd Banks. Comedian John Caparulo, comedian Whitney Cummings and comedian Donnell Rawlings.

4x160 - Jenny McCarthy

October 21, 2010

Jenny McCarthy is back with her latest book Love, Lust, and Faking It. Comedian Josh Wolf, musician Jeff Wild and comedian Guy Branum.

4x161 - Julian McMahon

October 25, 2010

From the film Red Julian McMahon graces us with his presence tonight. Comedian Jo Koy, actress-comedian Arden Myrin, and TV personality Ross Mathews.

4x162 - Milla Jovovich

October 26, 2010

Milla Jovovich returns to tell us about her new film Stone. Comedian Josh Wolf, comedian Chris Franjola and comedian Gary Valentine.

4x163 - Jennifer Nettles

October 27, 2010

Jennifer Nettles of Sugarland returns tonight with their new album The Incredible Machine. Comedian John Caparulo, comedian Sarah Colonna and comedian Chris Hardwick.

4x164 - Nick Swardson

October 28, 2010

From Nick Swardson's Pretend Time comedian Nick Swardson is here. Comedian Brad Wollack, comedian Michelle Collins and comedian Bobby Lee.

4x165 - Eddie Izzard

November 1, 2010

Eddie Izzard from Showtime's United States of Tara is here. Comedian Jo Koy, comedian Natasha Leggero and comedian Ryan Stout.

4x166 - Benji & Joel Madden

November 2, 2010

Benji and Joel Madden are here to tell us all about Good Charlotte's new album Cardiology. Comedian Josh Wolf, comedian Heather McDonald and comedian Bill Bellamy.

4x167 - Emily Procter

November 3, 2010

Probably the most pregnant cast member of CSI: Miami, Emily Procter is here. Comedian Dan Levy, comedian Chris Franjola and comedian Sarah Colonna.

4x168 - Connie Britton

November 4, 2010

From dare I say the greatest television show of all time (Friday Night Lights), we welcome Tami Taylor herself, the Emmy-nominated Connie Britton. Writer Diablo Cody, comedian Guy Branum and TV personality Ross Mathews.

4x169 - Keenan Cahill

November 8, 2010

We've got YouTube sensation Keenan Cahill debuting his brand new video on the show tonight. Comedian Josh Wolf, comedian Chris Franjola and comedian Sarah Colonna

4x170 - Kendra Wilkinson-Baskett

November 9, 2010

Kendra Wilkinson-Baskett is here to tell us all about the new season of her show Kendra. Comedian Jo Koy, comedian Matt Braunger and comedian Chris Hardwick

4x171 - Starsky & Cox

November 10, 2010

Find out how all of the stars align tonight with cosmic astrologists Starsky and Cox. Comedian Loni Love, comedian John Caparulo and TV personality Ross Mathews

4x172 - Florence Welch

November 11, 2010

Florence Welch, from one of this year's hottest acts, Florence + the Machine, is here. Comedian Jim Norton, comedian Brad Wollack and actress-comedian Arden Myrin

4x173 - Monica Potter

November 15, 2010

From one of the best shows on TV, Parenthood, Monica Potter is here. Comedian Josh Wolf, comedian Natasha Leggero and comedian Greg Proops

4x174 - Trey Songz

November 16, 2010

Trey Songz is bringing his Passion Pain and Pleasure (also the name of his new CD) to the show tonight, word. Comedian Jo Koy, comedian Heather McDonald and comedian T.J. Miller

4x175 - Tom Bergeron

November 17, 2010

Dancing With the Stars' extraordinary host and Deb's BFF (sorry, Gary) Tom Bergeron is here. Comedian Dan Levy, comedian Sarah Colonna and comedian Gary Valentine

4x176 - Nelly

November 18, 2010

Nelly is dropping by with his new album 5.0. This is for real, this is not just a dream...nailed it. Comedian Chris Franjola, E! News correspondent Michael Yo and TV personality Ross Mathews

4x177 - Single security guards

November 22, 2010

It's the return of Single Staffers...just in time for the holiday season, you're welcome America! Comedian John Caparulo, actress-Comedian Arden Myrin and comedian Ryan Stout.

4x178 - Dane Cook

November 23, 2010

Dane Cook is here with his greatest hits album, I Did My Best. Comedian Jo Koy, comedian Kevin Hart and comedian Ben Gleib

4x179 - Taylor Swift

November 24, 2010

Taylor Swift has a new album, called Speak Now, and she's here to tell us all about it. Topless comedian Brad Wollack, comedian Loni Love and comedian Gary Valentine

4x180 - Donald Schultz

November 26, 2010

Animal expert Donald Schultz is here with an alligator, a prairie dog and a rattlesnake. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews

4x181 - John Stamos

November 29, 2010

One of the greatest gifts television has ever given us, John Stamos who's been guesting on Glee is here. Comedian Josh Wolf, comedian Heather McDonald and TV personality Ross Mathews

4x182 - Flo Rida

November 30, 2010

Flo Rida is here with his new album Only 1 Flo and hopefully some explanation for the state of Florida. Comedian Jo Koy, comedian Sarah Colonna and comedian Mo Mandel

4x183 - Cee-Lo Green

December 1, 2010

Tonight we welcome The Lady Killer himself Cee-Lo Green. Topless Comedian Chris Hardwick, comedian Natasha Leggero and comedian Chris Franjola

4x184 - Kate Bosworth

December 2, 2010

From the new film The Warrior's Way Kate Bosworth is here. Comedian John Caparulo, comedian Matt Braunger and writer Diablo Cody

4x185 - Tom Arnold

December 6, 2010

4x186 - Lucy Liu

December 7, 2010

4x187 - Keri Hilson

December 8, 2010

4x188 - Kathy Griffi

December 9, 2010

4x189 - Nicki Minaj

December 13, 2010

4x190 - Cat Cora

December 14, 2010

4x191 - Ciara

December 15, 2010