4x134 - Ne-Yo

September 6, 2010

R&B singer Ne-Yo on his new album, "Libra Scale "; Round table discussion with comics Michael Yo, Jen Kirkman, and Ross Mathews.

4x135 - B.o.B.

September 7, 2010

VMA performer and five-time nominee B.o.B is here with his No. 1 album B.o.B Presents: The Adventures of Bobby Ray. Comedian Matt Braunger, comedian Heather McDonald and comedian Josh Wolf.

4x136 - Extra Roundtable

September 8, 2010

An extra-long Round Table. You're welcome, America. Comedian T. J. Miller, comedian Sarah Colonna and comedian Dov Davidoff.

4x137 - Extra Roundtable

September 9, 2010

An extra-long Round Table. You're welcome, America. Comedian Ben Gleib, actress-comedian Whitney Cummings and comedian Jo Koy.

4x138 - Emma Stone

September 13, 2010

From Easy A, the can-do-no-wrong-in-my-book Emma Stone is here. Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Kevin Hart.

4x139 - Snooki and Pauly D

September 14, 2010

Get ready to GTL because Jersey Shore's Snooki and Pauly D are back. Comedian Donnell Rawlings, comedian Natasha Leggero and comedian Brad Wollack.

4x140 - Usher

September 15, 2010

Usher has a new album, Versus, is on tour and is hanging out with us tonight, everyone rejoice. Comedian Loni Love, comedian Chris Franjola and musician Jeff Wild.

4x141 - Jared Leto

September 16, 2010

Jared Leto, lead singer of the band '30 Seconds to Mars.' Comedian John Caparulo, comedian Guy Branum and comedian Lavell Crawford

4x142 - Meghan McCain

September 20, 2010

We welcome author of Dirty Sexy Politics, Meghan McCain. Comedian Josh Wolf, comedian Heather McDonald and comedian Gary Valentine.

4x143 - Emily Rose

September 21, 2010

Emily Rose from SyFy's Haven is here. Comedian Matt Braunger, comedian Sarah Colonna and comedian Mo Mandel.

4x144 - Laird Hamilton

September 22, 2010

We're pretty stoked that world-renowned surfer Laird Hamilton returns tonight. Comedian Jason Sklar, comedian Michelle Collins and comedian Jo Koy.

4x145 - Kristen Bell

September 23, 2010

From the hilarious movie You Again, Jersey Shore's No. 1 fan Kristen Bell is here. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews.

4x146 - Adam Levine

September 27, 2010

Adam Levine of Maroon 5 is here with their new album Hands All Over. Comedian Brad Wollack, comedian John Caparulo and writer Diablo Cody.

4x147 - Taye Diggs

September 28, 2010

Star of Private Practice Taye Diggs is here…he may or may not be wearing a shirt. Comedian Jo Koy, comedian Dov Davidoff and comedian Natasha Leggero.

4x148 - Dax Shepard

September 29, 2010

Parenthood's Dax Shepard is here to discuss many a things, one being his new film The Freebie. Comedian Chris Franjola, comedian Dan Levy and TV personality Ross Mathews.

4x149 - AnnaLynne McCord

September 30, 2010

AnnaLynne McCord is here to give us the 411 on all things 90210. Comedian Chris Hardwick, comedian Ben Gleib and actress-comedian Arden Myrin.

4x150 - Duane "Dog" Chapman, Beth Smith Chapman,

October 4, 2010

Dog the Bounty Hunter's Beth and Duane "Dog" Chapman grace our stage tonight. Comedian Moshe Kasher, comedian Heather McDonald and comedian Josh Wolf.

4x151 - Tommy Lee

October 5, 2010

Tommy Lee is here with his latest Methods of Mayhem project A Public Disservice Announcement. TV personality Ross Mathews, comedian Whitney Cummings and comedian Guy Branum.

4x152 - Kelly Osbourne

October 6, 2010

Cohost of E!'s Fashion Police, Kelly Osbourne, is here. Comedian Jo Koy, comedian Randy Sklar and comedian Loni Love.

4x153 - Trace Adkins

October 11, 2010

The cowboy himself, Trace Adkins, is back with his new album Cowboy's Back in Town. Comedian Brad Wollack, comedian Chris Hardwick and comedian Natasha Leggero.

4x154 - Leah Remini

October 12, 2010

Cohost of the new CBS talk show The Talk, Leah Remini is here. Comedian Jo Koy, comedian Sarah Colonna and comedian Greg Proops.

4x155 - Lauren Conrad

October 13, 2010

Author of Sugar and Spice and Lauren Conrad Style the very busy Lauren Conrad is here. Comedian John Caparulo, comedian Josh Wolf and comedian Jim Breuer.

4x156 - Amy Brenneman

October 14, 2010

From Private Practice, the delightful Amy Brenneman returns to the show tonight. Comedian Chris Franjola, actress-comedian Arden Myrin and comedian Kevin Hart.

4x157 - Johnny Knoxville

October 18, 2010

The biggest jackass of them all, Johnny Knoxville from Jackass 3D is here. Comedian Ben Gleib, comedian Loni Love and TV personality Ross Mathews.

4x158 - Blake Shelton

October 19, 2010

The newest member of the Grand Ole Opry, Blake Shelton is here with his new album All About Tonight. Comedian Jo Koy, comedian Heather McDonald and E!'s own Michael Yo.

4x159 - Lloyd Banks

October 20, 2010

Rapper Lloyd Banks. Comedian John Caparulo, comedian Whitney Cummings and comedian Donnell Rawlings.

4x160 - Jenny McCarthy

October 21, 2010

Jenny McCarthy is back with her latest book Love, Lust, and Faking It. Comedian Josh Wolf, musician Jeff Wild and comedian Guy Branum.

4x161 - Julian McMahon

October 25, 2010

From the film Red Julian McMahon graces us with his presence tonight. Comedian Jo Koy, actress-comedian Arden Myrin, and TV personality Ross Mathews.

4x162 - Milla Jovovich

October 26, 2010

Milla Jovovich returns to tell us about her new film Stone. Comedian Josh Wolf, comedian Chris Franjola and comedian Gary Valentine.

4x163 - Jennifer Nettles

October 27, 2010

Jennifer Nettles of Sugarland returns tonight with their new album The Incredible Machine. Comedian John Caparulo, comedian Sarah Colonna and comedian Chris Hardwick.

4x164 - Nick Swardson

October 28, 2010

From Nick Swardson's Pretend Time comedian Nick Swardson is here. Comedian Brad Wollack, comedian Michelle Collins and comedian Bobby Lee.

4x165 - Eddie Izzard

November 1, 2010

Eddie Izzard from Showtime's United States of Tara is here. Comedian Jo Koy, comedian Natasha Leggero and comedian Ryan Stout.

4x166 - Benji & Joel Madden

November 2, 2010

Benji and Joel Madden are here to tell us all about Good Charlotte's new album Cardiology. Comedian Josh Wolf, comedian Heather McDonald and comedian Bill Bellamy.

4x167 - Emily Procter

November 3, 2010

Probably the most pregnant cast member of CSI: Miami, Emily Procter is here. Comedian Dan Levy, comedian Chris Franjola and comedian Sarah Colonna.

4x168 - Connie Britton

November 4, 2010

From dare I say the greatest television show of all time (Friday Night Lights), we welcome Tami Taylor herself, the Emmy-nominated Connie Britton. Writer Diablo Cody, comedian Guy Branum and TV personality Ross Mathews.

4x169 - Keenan Cahill

November 8, 2010

We've got YouTube sensation Keenan Cahill debuting his brand new video on the show tonight. Comedian Josh Wolf, comedian Chris Franjola and comedian Sarah Colonna

4x170 - Kendra Wilkinson-Baskett

November 9, 2010

Kendra Wilkinson-Baskett is here to tell us all about the new season of her show Kendra. Comedian Jo Koy, comedian Matt Braunger and comedian Chris Hardwick

4x171 - Starsky & Cox

November 10, 2010

Find out how all of the stars align tonight with cosmic astrologists Starsky and Cox. Comedian Loni Love, comedian John Caparulo and TV personality Ross Mathews

4x172 - Florence Welch

November 11, 2010

Florence Welch, from one of this year's hottest acts, Florence + the Machine, is here. Comedian Jim Norton, comedian Brad Wollack and actress-comedian Arden Myrin

4x173 - Monica Potter

November 15, 2010

From one of the best shows on TV, Parenthood, Monica Potter is here. Comedian Josh Wolf, comedian Natasha Leggero and comedian Greg Proops

4x174 - Trey Songz

November 16, 2010

Trey Songz is bringing his Passion Pain and Pleasure (also the name of his new CD) to the show tonight, word. Comedian Jo Koy, comedian Heather McDonald and comedian T.J. Miller

4x175 - Tom Bergeron

November 17, 2010

Dancing With the Stars' extraordinary host and Deb's BFF (sorry, Gary) Tom Bergeron is here. Comedian Dan Levy, comedian Sarah Colonna and comedian Gary Valentine

4x176 - Nelly

November 18, 2010

Nelly is dropping by with his new album 5.0. This is for real, this is not just a dream...nailed it. Comedian Chris Franjola, E! News correspondent Michael Yo and TV personality Ross Mathews

4x177 - Single security guards

November 22, 2010

It's the return of Single Staffers...just in time for the holiday season, you're welcome America! Comedian John Caparulo, actress-Comedian Arden Myrin and comedian Ryan Stout.

4x178 - Dane Cook

November 23, 2010

Dane Cook is here with his greatest hits album, I Did My Best. Comedian Jo Koy, comedian Kevin Hart and comedian Ben Gleib

4x179 - Taylor Swift

November 24, 2010

Taylor Swift has a new album, called Speak Now, and she's here to tell us all about it. Topless comedian Brad Wollack, comedian Loni Love and comedian Gary Valentine

4x180 - Donald Schultz

November 26, 2010

Animal expert Donald Schultz is here with an alligator, a prairie dog and a rattlesnake. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews

4x181 - John Stamos

November 29, 2010

One of the greatest gifts television has ever given us, John Stamos who's been guesting on Glee is here. Comedian Josh Wolf, comedian Heather McDonald and TV personality Ross Mathews

4x182 - Flo Rida

November 30, 2010

Flo Rida is here with his new album Only 1 Flo and hopefully some explanation for the state of Florida. Comedian Jo Koy, comedian Sarah Colonna and comedian Mo Mandel

4x183 - Cee-Lo Green

December 1, 2010

Tonight we welcome The Lady Killer himself Cee-Lo Green. Topless Comedian Chris Hardwick, comedian Natasha Leggero and comedian Chris Franjola

4x185 - Tom Arnold

December 6, 2010

4x186 - Lucy Liu

December 7, 2010

4x187 - Keri Hilson

December 8, 2010

4x188 - Kathy Griffi

December 9, 2010

4x189 - Nicki Minaj

December 13, 2010

4x190 - Cat Cora

December 14, 2010

4x191 - Ciara

December 15, 2010

4x192 - Amy Adams

December 16, 2010

4x193 - Diddy-Dirty Money

December 20, 2010

4x194 - Reese Witherspoon

December 21, 2010

4x195 - Crystal Bowersox

December 22, 2010

4x196 - Natasha Bedingfield

December 27, 2010

4x197 - Keyshia Cole

December 29, 2010