6x1 - Richard Lewis

January 9, 2001

6x2 - Vitamin C

January 10, 2001

6x3 - Julia Stiles

January 11, 2001

6x4 - William Dafoe

January 15, 2001

6x5 - Tim Robbins

January 16, 2001

6x6 - Sam Donaldson

January 17, 2001

6x7 - Lynn Whitfield

January 18, 2001

6x8 - Bill O'Reilly

January 22, 2001

6x9 - Matthew McConaughey

January 23, 2001

6x10 - Terry Bradshaw

January 24, 2001

6x11 - Topher Grace

January 25, 2001

6x12 - David Boreanaz

January 29, 2001

6x13 - Dyan Cannon

January 30, 2001

6x14 - James van der Beek

January 31, 2001

6x15 - Tim Blake Nelson

February 1, 2001

6x16 - Dave Grohl

February 12, 2001

6x17 - Kermit the Frog

February 13, 2001

6x18 - Jessica Alba

February 14, 2001

6x19 - Wanda Sykes

February 15, 2001

6x20 - Greg Germann

February 20, 2001

6x21 - Chris Rock

February 21, 2001

6x22 - Kelly Ripa

February 22, 2001

6x23 - Ted Danson

February 26, 2001

6x24 - Joe Pantoliano

February 27, 2001

6x25 - Heather Locklear

February 28, 2001

6x26 - Warren Christopher

March 1, 2001

6x27 - Martin Short

March 5, 2001

6x28 - Ed Burns

March 6, 2001

6x29 - Carmen Electra

March 7, 2001

6x30 - Javier Bardem

March 8, 2001

6x31 - Chris Meloni

March 19, 2001

6x32 - Mary Stuart Masterson

March 20, 2001

6x34 - Denis Leary

March 22, 2001

6x35 - Richard Roeper

March 26, 2001

6x36 - Richard Lewis

March 27, 2001

6x37 - Mark Harmon

March 28, 2001

6x38 - Jennifer Love Hewitt

March 29, 2001

6x39 - Lisa Ling

April 2, 2001

6x40 - Amy Sedaris

April 3, 2001

6x41 - D.L. Hughley

April 4, 2001

6x42 - Steven Weber

April 5, 2001

6x43 - Paul Reubens

April 9, 2001

6x44 - Bob Costas

April 10, 2001

6x45 - Damon Wayans

April 11, 2001

6x46 - Brittany Daniel

April 12, 2001

6x47 - Don Hewitt

April 23, 2001

6x48 - Rachael Leigh Cook

April 24, 2001

6x49 - Tom Green

April 25, 2001

6x50 - Tom Cavanagh

April 26, 2001

6x51 - Eric McCormack

April 30, 2001

6x52 - Dominic Chianese

May 1, 2001

6x53 - No Guest

May 2, 2001

6x54 - Robert Patrick

May 3, 2001

6x55 - Chris Robinson

May 7, 2001

6x56 - James Van Der Beek

May 8, 2001

6x57 - Richie Sambora

May 9, 2001

6x58 - Patricia Richardson

May 10, 2001

6x59 - Maura Tierney

May 14, 2001

6x60 - Denise Quiñones

May 15, 2001

6x61 - Heath Ledger

May 16, 2001

6x62 - Jerry Springer

May 17, 2001

6x63 - Richard Schiff

May 29, 2001

6x64 - Bradley Whitford

May 30, 2001

6x65 - Leah Remini

May 31, 2001

6x66 - Jake Johannsen

June 4, 2001

6x67 - Richard Belzer

June 5, 2001

6x68 - Al Roker

June 6, 2001

6x69 - Bernie Mac

June 7, 2001

6x70 - Joe Queenan

June 11, 2001

6x71 - Gene Simmons

June 12, 2001

6x72 - David Duchovny

June 13, 2001

6x73 - Jeff Greenfield

June 14, 2001

6x74 - Martin Short

June 18, 2001

6x75 - Michael Rapaport

June 19, 2001

6x76 - Alec Baldwin

June 20, 2001

6x77 - Mýa

June 21, 2001

6x78 - Sam Robards

June 25, 2001

6x79 - Johnny Knoxville

June 26, 2001

6x80 - Jet Li

June 27, 2001

6x81 - Bridget Fonda

June 28, 2001

6x82 - Sean Hayes

July 9, 2001

451. Sean Hayes First aired: 7/9/2001 Production Code: 6001 Tonight, actor Sean Hayes from Will & Grace.

6x83 - The Spice Girls

July 10, 2001

452. Spice Girls First aired: 7/10/2001 Production Code: 6002 Tonight, the Spice Girls. Replay of Posh & Baby Spice Interview from (2000-10-25).