6x33 - Jeff Varner

March 21, 2001

6x34 - Denis Leary

March 22, 2001

6x35 - Richard Roeper

March 26, 2001

6x36 - Richard Lewis

March 27, 2001

6x37 - Mark Harmon

March 28, 2001

6x38 - Jennifer Love Hewitt

March 29, 2001

6x39 - Lisa Ling

April 2, 2001

6x40 - Amy Sedaris

April 3, 2001

6x41 - D.L. Hughley

April 4, 2001

6x42 - Steven Weber

April 5, 2001

6x43 - Paul Reubens

April 9, 2001

6x44 - Bob Costas

April 10, 2001

6x45 - Damon Wayans

April 11, 2001

6x46 - Brittany Daniel

April 12, 2001

6x47 - Don Hewitt

April 23, 2001

6x48 - Rachael Leigh Cook

April 24, 2001

6x49 - Tom Green

April 25, 2001

6x50 - Tom Cavanagh

April 26, 2001

6x51 - Eric McCormack

April 30, 2001

6x52 - Dominic Chianese

May 1, 2001

6x53 - No Guest

May 2, 2001

6x54 - Robert Patrick

May 3, 2001

6x55 - Chris Robinson

May 7, 2001

6x56 - James Van Der Beek

May 8, 2001

6x57 - Richie Sambora

May 9, 2001

6x58 - Patricia Richardson

May 10, 2001

6x59 - Maura Tierney

May 14, 2001

6x60 - Denise Quiñones

May 15, 2001

6x61 - Heath Ledger

May 16, 2001

6x62 - Jerry Springer

May 17, 2001

6x63 - Richard Schiff

May 29, 2001

6x64 - Bradley Whitford

May 30, 2001

6x65 - Leah Remini

May 31, 2001

6x66 - Jake Johannsen

June 4, 2001

6x67 - Richard Belzer

June 5, 2001

6x68 - Al Roker

June 6, 2001

6x69 - Bernie Mac

June 7, 2001

6x70 - Joe Queenan

June 11, 2001

6x71 - Gene Simmons

June 12, 2001

6x72 - David Duchovny

June 13, 2001

6x73 - Jeff Greenfield

June 14, 2001

6x74 - Martin Short

June 18, 2001

6x75 - Michael Rapaport

June 19, 2001

6x76 - Alec Baldwin

June 20, 2001

6x77 - Mýa

June 21, 2001

6x78 - Sam Robards

June 25, 2001

6x79 - Johnny Knoxville

June 26, 2001

6x80 - Jet Li

June 27, 2001

6x81 - Bridget Fonda

June 28, 2001

6x82 - Sean Hayes

July 9, 2001

451. Sean Hayes First aired: 7/9/2001 Production Code: 6001 Tonight, actor Sean Hayes from Will & Grace.

6x84 - James Woods

July 11, 2001

6x85 - Vince Vaughn

July 12, 2001

6x86 - Jon Favreau

July 16, 2001

6x87 - Maria Bartiromo

July 17, 2001

6x88 - Ed Norton

July 18, 2001

6x89 - Hank Azaria

July 19, 2001

6x90 - Larry Miller

July 23, 2001

6x91 - Paul Giametti

July 24, 2001

6x92 - Senator Joe Lieberman

July 25, 2001

6x93 - Senator John McCain

July 26, 2001

6x94 - Jerri Manthey

July 30, 2001

6x95 - Peter Krause

July 31, 2001

6x96 - Jackie Chan

August 1, 2001

6x97 - Janeane Garofalo

August 2, 2001

6x98 - Andie MacDowell

August 6, 2001

6x99 - Joe Rogan

August 7, 2001

6x100 - Tara Reid

August 8, 2001

6x101 - Jason Biggs

August 9, 2001

6x102 - David Rakoff

August 13, 2001

6x103 - John Carpenter

August 14, 2001

6x104 - Seth Green

August 15, 2001

6x105 - Fabio

August 16, 2001

6x106 - Cuba Gooding Jr.

August 20, 2001

6x107 - Griffin Dunne

August 21, 2001

6x108 - Will Ferrell

August 22, 2001

6x109 - Kevin Smith

August 23, 2001

6x110 - They Might Be Giants

September 10, 2001

6x111 - Dave Navarro

6x112 - September 20, 2001 - The Comeback episode

September 20, 2001

The Daily Show returns to the air from the New York studio in their first episode after the tragedy of September 11th, 2001.

6x113 - Frank Rich

September 24, 2001

6x114 - Aaron Brown

September 25, 2001

6x115 - Jeff Greenfield

September 26, 2001

6x116 - Tenacious D

September 27, 2001

6x117 - Kelsey Grammer

October 1, 2001

6x118 - Jim Belushi

October 2, 2001

6x119 - Stephen Morse

October 3, 2001

6x120 - Kate Beckinsale

October 4, 2001

6x121 - Owen Wilson

October 9, 2001

6x122 - Jeremy Piven

October 10, 2001

6x123 - John Miller

October 11, 2001

6x124 - Emeril Lagasse

October 15, 2001

6x125 - Lorraine Bracco

October 16, 2001

Tonight, actress Lorraine Bracco from The Sopranos.

6x126 - Snoop Dogg

October 17, 2001

6x127 - Fareed Zakaria

October 18, 2001

6x128 - Lance Bass

October 22, 2001

6x129 - Don Dahler

October 23, 2001

6x130 - Greta Van Susteren

October 24, 2001

6x131 - Jeff Bridges

October 25, 2001

6x132 - Rob Morrow

October 30, 2001

6x133 - Richard Holbrooke

October 31, 2001